DEXLEVO Technology

History of CESABP technology

CESABP(Collagenesis-Enabled Solubilized Active and Biodegradable Polymer) Technology

There are lots of hyaluronic acid-based products in the market. However, Hyaluronic Acid is technically degradable in human body in a few days. That is, the effects after the injection won’t last up for a long time.

For this reason, some companies have made more concrete and strong hyaluronic acid dermal fillers by cross-linking the hyaluronic particles using BBDE or DVS. Those cross-linked fillers are so concrete that they could maintain for a long time. But, materials like BBDE or DVS have reported as a hazardous one.

To solve this problem, biocompatible and biodegradable polymer products were developed. The microparticles(the size of 20 to 50μm) of insolubilized polymer are dispersed in carboxymethylcellulose(CMC) gel or Glycerin liquid.

There are two types of polymer products commonly used in the market, poly lactic acid(PLA) and polycaprolactone(PCL). But, the size of those particles is so big that sometimes they are stuck in the needle. Also, there is a possibility of a blockage of veins. In addition, they are only proper to use on the localized part of the skin since it does not spread easily.

Dexlevo developed a fully solubilized biocompatible and biodegradable PCL. This solubilized PCL spreads easily into the extensive part of the skin. So, it won’t be necessary to inject multiple points. After injection, this dermal filler forms an extensive 3D matrix which makes it possible to last up for a long time without phagocytosis.

We call this technology as CESABP(Collagenesis-Enabled Solubilized Active and Biodegradable Polymer) Technology.

This is Dexlevo’s patented technology. This technology generates the collagen synthesis on the entire skin effectively. As a result, skin thickness, density and elasticity would be improved without lumps or nodules. And this is an innovation for fundamental anti-aging.

World’s unique technology of manufacturing of Solubilized PCL for natural skin collagen synthesis

Patent no.(KR) : 10-2018-0058947
Patent no.(US) : 16/410,611
Patent no.(PCT) : PCT/KR2018/005988